Metoprolol tartrate is a selective β1 receptor blocker used in treatment of several diseases of the cardiovascular system, especially for hypertension. Transdermal patches of Metaprolol tartarate were prepared by using different polymers such as Eudragit L100, Eudragit RL100, polyethylene glycol with different ratios. Solvent casting method was employed for the preparation of transdermal patches. The prepared patches were evaluated for flexibility, thickness, weight variation, moisture content, hardness and for tensile strength. The drug release studies were carried out using Franz diffusion cell with dialysis membrane as the diffusion medium. The prepared trandermal patches were further characterized by Fourier transform infrared spectroscopy, Differential scanning colourimetry and Scanning electron microscopic analysis. The drug release from the formulations with 1% eutragit L100, 1% eutragit RL100 was extended up to 24 hrs. The results of stability studies indicated that all patches were stable after storing that accelerated conditions. Compatibility studies indicated that there are no interactions between drug and excipient used.
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