Transdermal patches are pharmaceutical dosage forms of varying sizes, containing, one or more active ingredient, intended to be applied to the unbroken skin in order to deliver in to systemic circulation through the skin barriers. Transdermal drug delivery system (TDDS) is a non-invasive route of drug administration and also it allows drug to release in sustain fashion as well as reduces the intensity of action and the side effects associated with its oral therapy. The patches had been proved effective because of its diverse advantages over other controlled drug delivery systems. This review article covers a brief outline on structure of skin, routes of penetration through the skin, various components required for formulation of transdermal patch, kinetics of drug release and permeation through skin, different approaches and advanced techniques for development of TDDS, various methods for development and evaluation of transdermal system.
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