Oral administration is most popular route. About 40 to 50 % of novel chemical entities show poor bioavailability due to their low aqueous solubility. These drugs can be solublized to increase the bioavailability by using several methods as microemulsion, nanosuspension, liposome, solid lipid nanoparticles, self emulsifying drug delivery system (SEDDS), complexation with cyclodextrin etc. Self Micro-emulsifying Drug Delivery System (SMEDDS) is a novel approach to improve water solubility and ultimate bioavailability of drugs. SMEDDS is isotropic (one phase system) mixture of oil or modified oils, surfactants and co-surfactants, which are emulsified in aqueous media under conditions of gentle stirring and form the fine oil-in-water microemulsion, which presents the drug in solubilized form, and the small size of the formed droplet provides a large interfacial surface area for drug absorption. For lipophilic drugs, which display dissolution rate-limited absorption, SEDDS may be a promising strategy to improve the rate and extent of oral absorption.
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