There is considerable interest in the skin as a site of drug application both for local and systemic effect. Skin has always remained as the main part of drug delivery through last decades. There are many persons which you can see having patches attached to their body parts such as having it on the ear back for the vertigo like conditions, or alcohol dehydrogenase patch for alcohol de-addiction. This article deals with the how to enhance the delivery of drug through chemical and physical enhancers means how by they act, how they modify the structure of skin for transporting the drug through the skin and subsequently it will thus, it will help in the selection of suitable penetration enhancers for improving the permeation of poorly absorbed drugs via transdermal route.
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