Transdermal drug delivery system overcomes the problems associated with conventional oral dosage forms. It is painless delivery compare to intravenous delivery. MDTS (metered dose transdermal spray) is a monophasic solution containing drug with penetration enhancers. Combination of volatile-nonvolatile solvent system with penetration enhancers shows better penetration rate than the transdermal patch. On the application, MDTS forms thin non occlusive film of drug reservoir and release the drug in controlled manner for longer time. Steady state concentration is achieved from the stratum corneum reservoir. Dosing flexibility makes it more acceptable to the patient compared to transdermal patch.
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