The objective of present work was to develop ocular inserts of levofloxacin and evaluate their potential for controlled ocular delivery. Conventional ophthalmic solution shows the poor bioavailability and therapeutic response due to many precorneal constraints. These constrains necessitates the controlled drug delivery to become a standard one in modern pharmaceutical era. Matrix type ocular inserts containing different combination of HPMC K 100 and Ethyl cellulose E7. The ocular insert were prepared by solvent casting technique and characterized thickness, hardness, weight variation, drug content, moisture loss, moisture absorbed, hydrolytic study, sterility study and In vitro drug release study. All the ocular inserts were found to be stable to all physiological studies. Among all batches F5 batch shows best result and optimized formula (HPMC K100 & EC N7 in 300 mg and 400 mg) sustained releases.
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