One of the most potential routes of the systemic drug delivery system is transdermal route with the advantage of avoidance of first pass effect, ease of application and removal and better patient compliance. Stratum corneum is one of the layers of skin which possess formidable barrier to drug penetration and thereby causing problems of bioavailability of drug. Ethosomes, a non-invasive delivery carrier system recognized as ethanolic phospholipid vesicles as it mainly consist of high concentration of ethanol and phospholipids. Ethosomes are the best alternative to liposomes and transferosomes as ethanol overcome the problem of entering to stratum corneum by increasing penetration rate. The purpose of writing this review on ethosomes drug delivery was to study different patents and to study how ethosomes actually works, what is the mechanism of penetration and how it can be used as an alternative, along with its method of preparation and their evaluation. Characterization of ethosomes include entrapment efficiency, vesicle size, shape, diffusion studies, and zeta potential and stability studies.
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