The objective of this study was to summarize the preparation and application of water-in-oil-in-water type multiple emulsions (w/o/w emulsions) entrapping Risedronate sodium. Formulations of the emulsions (the composition of an oily phase or the type and concentrations of surfactants) and emulsification method or conditions (rotation rates and operation times) were evaluated in order to prepare stable w/o/w emulsions. The pharmaceutical properties of the w/o/w emulsions ââ?¬â? particle sizes, viscosity, phase separation and drug entrapment efficiency were measured and evaluated. We prepared stable w/o/w emulsions with a particle size of about 2 micron and an entrapment efficiency of Risedronate sodium of about 70%. When these emulsions were investigated for permeability studies enhanced permeation was observed to that of Risedronate sodium solution alone. The results of this study showed the potential of the w/o/w emulsions for several clinical applications as one of the drug delivery systems.
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