The study was aimed to prolong gastric residencetimeandimprovebioavailability of model drug, Rosuvastatin calcium by developing gastroretentive floating drug delivery systems, particularly effervescent floating tablets.Effervescent floating drug delivery tablets were prepared by direct compression method. A three-factor, three levels Box-Behnken design was adopted for the optimization. The selected independent variables were amount of hydroxyl propyl methyl cellulose K100M (X1), sodium carboxy methylcellulose (X2) and guar gum (X3). The dependent variables were floating lag time (YFLT), cumulative percentage of rosuvastatin calcium released at 6th h (Y6) and cumulative percentage of rosuvastatin calciumreleased at 12th h (Y12). Physical properties, % drug content, in vitrobuoyancy study and % drug release behavior were assessed. Optimum formulation R10 showed floating lag time of 22 s, floated for more than 12 h and released the drug of 98.23�±0.92% in sustained manner. Stability studies revealed that no significant changein In vitro floating lag time, total floating time, % drug content and drug release behavior before and after storage. The effervescent-based floating drug delivery isa promising approach to improve oral bioavailability by using a combination of synthetic and natural swellable polymers. Shorter floating lag time and drug release in a sustained manner was achieved by using Box-Behnken design.
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