The aim of the present work was formulation and evaluation of in situ gelling system of Neomycin sulphate Neomycin sulphate for the treatment of bacterial conjunctivitis is 1 or 2 drops of 0.5% solution(3.5 mg) in the affected eyes for every 3 to 4 hours up to 4 times for days. A combination of carbopol and methyl cellulose, sodium alginate was investigated as a vehicle for the formulation of eye drops of Neomycin sulphate (0.5%) to form gel when instilled into the eye to provide sustained release of the drug to improve the patient compliance by reducing the frequency of administration. The formulated Neomucin sulphate ocular in-situ gel were then evaluated for Visual appearance and clarity, pH of formulation, Rheological study, Adhesive study, Gelling capacity, Drug content, In vitro drug release, Sterility test, Stability study. The in vitro drug release studies were carried out using Bi-chambered donar receiver compartment model. In vitro drug release kinetic data was treated according to Zero, First, and Higuchi kinetics to access the mechanism of drug release. Formulation NF5, NF6, NF9, NF11 and NF12 showed sustained drug release for a period of 10 hour. Formulation NF11 showed most sustained drug release. It was observed that NF5, NF6, NF9, NF11 and NF12 formulations followed the zero order or near zero order drug release, suggesting drug release in a controlled manner. Results of sterility test confirmed that an optimized formulation was sterile. Formulation NF11 was selected best formula based on release rate and other evaluation parameters.
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