Mouth dissolving tablets are most preferred formulations used in the pharmaceutical field. To improve patient�s compliance scientists have always being working towards the production of new drug delivery systems. From the various existing drug delivery systems mouth dissolving drug delivery systems have been proved most effective in overcoming previously encountered administration problems. Mouth dissolving drug delivery system was first developed in the late 1970s as an alternative to capsule, tablet & syrups. MDTs are unit solid dosage form which disintegrates rapidly in the saliva generally in less than 60 seconds when placed on the tongue provide fast onset of action. In elderly patients suffering from dysphagia and hand tremors mouth dissolving tablets are first line treatment drugs. Talking of various problems like difficulty in swallowing and age related problems mouth dissolving tablets have been formulated for paediatrics, geriatric, and bedridden patients and for active patients who are busy and travelling and may not have access to water. Some patented technologies like orasolv, durasolv, wowtab, flashtab, zydis, oraquick, advatab, quickdisc, and nanomelt have be introduced by some pharmaceutical companies for the production of MDTs. The aim of this review article is to compile the developments in the field of new MDTs technologies, stability of drug candidate and future prospects. \r\nKeywords: Oral drug delivery system, mouth dissolving tablets, superdisintegrants
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