The purpose of this study was to compare the lansoprazole efficacy in chitosan nanoparticles and PLGA nanoparticles to identify the optimized formulation and to choose a opt carrier. For these ten formulations of chitosan nanoparticles (CNP1 to CNP10) and ten formulations of PLGA (PNP1 to PNP10) were prepared. The optimized formulations of chitosan nanoparticles (CNP5) and PLGA nanoparticles (PNP7) were taken for the comparative study. The results revealed that, nanoparticles prepared with PLGA possessed ideal characters than the nanoparticles prepared with chitosan.
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