To develop and evaluate Isosorbide dinitrate microspheres using chitosan as a polymer. Isosorbide dinitrate is anti-anginal with low bioavailability (25 %) from the gastrointestinal tract. The poor bioavailability and short biological half-life of 1 hour sufficient for the development of sustained release formulation. Microspheres of Isosorbide dinitrate were prepared by emulsion cross-linking method by using chitosan as a polymer. Various parameters were assessed, with a view to obtain oral sustained release of Isosorbide dinitrate. In the present study nine formulations were formulated by using chitosan in various proportions. The prepared microsphere were then subjected to FT-IR, SEM, particle size, % yield, drug loading, entrapment efficiency, in vitro dissolution study, release kinetics and DSC. The FT-IR spectra and DSC revealed that, there was no interaction between polymer and Isosorbide dinitrate. Microspheres are spherical in nature, which was confirmed by SEM. A maximum of 90.06 % drug entrapment efficiency was obtained. The in vitro performance of microspheres showed sustain release depend on polymer concentration. The co-efficient of determination indicated that the release data was best fitted with zero order kinetics. The present study conclusively demonstrates the feasibility of effectively encapsulating Isosorbide dinitrate into chitosan to form a multiple drug delivery device.
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