The main objective of the present study is physicochemical characterization of gum exudates of Terminalia catappa Linn (Almond gum/AG gum) as a hydrophilic sustained release versatile natural pharmaceutical excipient. This natural AG gum is not explore very well as compare to other natural polymer/gums such as xanthan gum, locust bean gum, guar gum, tamarind gum etc. In the present experiment we are explaining collection, purification& characterization of AG gum & also the physicochemical properties such as flow properties, solubility behaviour, rheological properties, microbial limit test, melting point, pH & water retention capacity was evaluated. The AG gum was also characterized by X-ray diffraction, Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR). Sustained release matrix tablet AGgum was prepared with drug Alfuzosin HCl by direct compression, aqueous granulation and non-aqueous granulation. All formulation techniques showed reduction of dissolution rate. Aqueous granulation showed the maximum sustained release up to 15 hr. as compare to direct compression & non-aqueous granulation techniques. F8 (105mg AG gum) was selected as an optimized formulation based on its 15 hr. drug release. These results showed that AG gum in the concentration 70 & 105 mg exhibited sufficient sustained drug release. Thus the study confirmed that AG gum might be used in tablets as release retarding natural polymer.
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