Psoriasis is an autoimmune disease caused by inappropriate activation of the cellular immune system. Psoriasis vulgaris is a common skin disorder characterized by focal formation of inflamed, raised plaques, with relapsing episodes of inflammation and hyperkeratosis. Various approaches have been opted to treat this disease using different antipsoriatics with different modes of action and routes of administration. But, till now there is no such medication which can completely cure the disease with least side effects. The main reason behind this is the lack of ideal carrier which can deliver drug effectively and safely. Effective psoriasis treatments have been introduced as a result of the continuous advancements in developing novel formulations related to colloidal carriers systems such as like liposome, niosomes, ethosomes, solid lipid nanoparticles, microspheres, dendrimers, micelles etc. Present review is an endeavoring attempt to envisage on psoriasis in terms of pathogenesis, currently available treatment options present in both conventional and novel systems, marketed products based on colloidal carriers, side effects of individual antipsoriatic drugs, major hindrances in psoriasis treatment and their future prospective.
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