Fungal infection of the skin is one of the most common problems faced with dermatological diseases in worldwide. Topical therapy is a most suitable choice for the treatment of the cutaneous infections. Azoles are the most commonly used antifungals in the clinical treatment of local and systemic fungal infections. Topical therapy for fungal infection is advantageous because the drugs are targeting to the site of infection and reduces the risk of systemic side effects. Formulation design and optimization are key steps for increasing the therapeutic efficacy. Recently, the fungal infection of the skin the antifungal drugs generally used as conventional cream and gel preparation for the treatment. The effectiveness of that treatment is mainly depends on the permeation of drugs through the targeting layer of skin. The stratum corneum of the skin acts as a principle barrier to the permeation of topically applied drugs. The physiochemical properties of drug molecule and formulation type are most useful factors in topical drug delivery system. Therefore, a number of new advances in formulation have been investigated for delivering antifungal drugs through skin target site. This review focuses on recent advances in topical formulation approaches to improve the penetration of antifungal drugs through skin.
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