The objective of present work was to formulate floating pulsatile microspheres of ivabradine hydrochloride intended for chronopharmacotherapy of angina pectoris. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having a lag phase during floating in acidic medium followed by burst release in basic medium. These microspheres were prepared by non aqueous solvent evaporation technique using Eudragit S100 which is a pH dependent polymer that gets solubilized at pH 7 and above. Ivabradine hydrochloride is categorized as If channel antagonist, water soluble drug and was selected as model drug for treatment of angina pectoris which rely on circadian rhythm. Moreover it has short half life (2 hours), it undergoes extensive first pass metabolism. All these factors contribute to formulate ivabradine hydrochloride as floating pulsatile microspheres. These microspheres were evaluated for micromeritic properties, particle size, entrapment efficiency, in-vitro floating ability, drug release and kinetics of microspheres. The optimized formulation exhibited good entrapment efficiency, flow properties, floating property and released the drug at right time by maintaining required lag phase and followed first order kinetics.
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