The purpose of the present study was to develop oro‐dispersible tablet containing rizatriptan benzoate using natural, synthetic and ion exchange resin superdisintegrants. Migraine is a common headache disorder that imposes a substantial burden on both the individual patient and society. Typically, migraines are intense with >80% of patients describing their pain as severe. Rizatriptan benzoate is a potent and selective 5-HT1B/1D receptor agonist and is effective for the treatment of acute migraine. Conventional rizatriptan benzoate tablets available in market are not suitable where quick onset of action is required, the enzymatic degradation in the gastrointestinal tract and first-pass metabolism in the liver can be avoided. Thus, mouth dissolving tablets can potentially achieve high bioavailability and rapid onset of desirable action in a convenient manner. To provide the patients with the most conventional mode of administration, there was a need to develop rapidly disintegrating dosage form, particularly one that disintegrates and dissolves/disperses in saliva and can be administered without need of water. Hence orodispersible tablet was formulated by direct compression that can be administered orally to get rapid onset of action. A total 9 batches (F1-F9) were formulated using three categories of superdisintegrants viz. natural, synthetic and ion exchange resin in three different concentrations. To mask the bitter taste of drug, aspartame is added as sweetener. The tablets were prepared by direct compression technique. Thickness, hardness, friability, weight variation, disintegration test, in-vitro dissolution study and uniformity of content were evaluated for each formulation and found satisfactory. Natural superdisintegrants, gives a rapid disintegration and high release as compared to synthetic superdisintegrants in formulation of orally disintegrating tablet of rizatriptan. The drug release of the optimized batch (F6) obtained was 95.6% within 15 min which is higher than the marketed conventional tablet. Optimized batch is evaluated for masking of bitter taste using E-tongue.
Loading....