The main objective of present study was prepation of Zaltoprofen loaded gelatin nanoparticles (Z-GNP) by nanoprecipitation to sustained release of Zaltoprofen from its nanoparticulate carriers. The zaltoprofen loaded gelatin nanoparticles (Z-GNP) were prepared by nanoprecipitation method. (Z-GNP) were characterized by particle size, entrapment efficiency, drug loading, yield of nanoparticles, Qualitative determination of crosslinking efficiency, Scanning electron microscopy(SEM), differential scanning calorimetry (DSC), in–vitro drug release studies, fourier transform infrared (FT-IR) spectroscopy. The particle size, entrapment efficiency and drug loading of (Z-GNP) of optimized formulation (GN 5) was found to be 352 nm, 73.11%, 27.19% respectively. In-vitro drug release in phosphate buffer saline (pH 7.4) was maximum (63.45%) in 48 hrs. and shows sustained release action. Glutaradehyde used to cross-link the gelatin nanoparticles and Qualitative determination of crosslinking efficiency by Potentiometric titration. The principle parameters studied for its optimum conditions were the ratio of drug, surfactant and polymer was found to be 0.48:32:1. The pluronic F-127 used to prevent aggregation of gelatin nanoparticles generally observed in previous two step desolvation method. The result of DSC and FTIR were compared with reference gives no chemical interaction and stability of zaltoprofen in gelatin nanoparticles. It can be confirmed that, the drug (Zaltoporfen) release from gelatin nanoparticles was sustained in 7.4 pH buffer.
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