Oral route has always been preferred route for formulation and dominated over other routes of administration. However this preferred route is limited to those drugs molecule that are permeable across the gastric mucosa and are at least sparingly soluble. Thymoquinone is an anticancer, anti-arthritis and anti-inflammatory agent having poor oral solubility. Objective of present study was to increase solubility of thymoquinone with the help of self-micro emulsifying drug delivery system D-optimal mixture design. Solubility of thymoquinone was found in various oils (synthetic and edible) and co-surfactant ratio with saturation increment method, from that pseudoternary phase diagram was prepared for selection of oil, surfactant and co-surfactant ratio. D-optimal mixture design was used to formulate SMEDDS. Formulations were optimized for viscosity, % transmittance, globule size, zeta potential, TEM and pH.
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