Despite phenomenal advances in the injectable, inhalable, transdermal, nasal and other delivery systems, the oral route is still considered the most preferable for both patients and industry. Being natural, noninvasive and safe method of drug delivery, oral delivery is, always, associated with high degree of patient compliance. On the other hand, oral delivery systems are able to accommodate various physicochemical properties of drugs, do not require strict sterile conditions and therefore less expensive to manufacture. Thus, even small improvements in oral drug delivery technology can make significant difference in enhancing patient compliance and drug delivery fields in general. Over the past decades, several novel technologies for oral delivery have been developed, examples include; oral rapid disintegrating (dissolving) tablets, mucoadhesive buccal dosage forms, site specific drug delivery and novel controlled release dosage forms. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for MDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research area.
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