The aim of this study was to design and characterize press coated tablet of carvedilol for colon targeted drug delivery. The drug delivery system was based on the gastrointestinal transit time concept, assuming colon arrival time to be 5 h. To improve the solubility and dissolution rate of carvedilol inclusion complex was prepared by kneading method. Core tablet was prepared by direct compression using superdisintegrants sodium starch glycolate and crosscarmellose sodium. The core tablet was compression coated with different quantities of coating material containing different polymers. A 32 full factorial design was used for optimization of barrier layer. The ratio of hydroxypropylmethylcellulose K100M: Ethyl cellulose (X1) and coat weight (X2) were selected as independent variables. The lag time and percentage drug release at 12 h (Q12) were selected as dependent variables. Tablets were evaluated for hardness, friability, weight variation, drug content, in-vitro drug release and stability study. Comparative dissolution profiles of all the batches indicate drug release from tablet was inversely proportional to coat weight. The kinetics release of optimize batch P5 was best explained by zero order and Korsmeyerââ?¬â??Peppas kinetic model. The press coated tablets coated with HPMC K100M: EC in 50:50 ratios with 230 mg coat weight were most likely to provide targeted delivery of carvedilol to the colon.
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