Topical therapy is a most suitable choice for the treatment of the skin infections. Topical therapy for skin infection is advantageous because the drugs are targeting to the site of infection and reduces the risk of systemic side effects. The effectiveness of that treatment is mainly depends on the permeation of drugs through the targeting layer of skin. The skin is composed of three layers: the epidermis, the dermis and subcutaneous tissue. The skin is the largest organ of the body, accounting for about 15% of the total adult body weight. The stratum corneum of the skin acts as a principle barrier to the permeation of topically applied drugs. There are three ways in which a drug molecule can cross the intact stratum corneum: via skin appendages, intercellular lipid domains and transcellular route. This review article mainly focuses on the role and functions of skin for topical drug delivery used in the treatment of various skin infections and anatomy and physiology of the skin. The present study deals with the study of drug penetration across the skin and its kinetics.
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