Objective of present work was design and development of taste masked orodispersible tablet of raloxifene hydrochloride (HCl). In current research, the orodispersible tablets of antiosteoporetic agent, raloxifene hydrochloride were formulated by direct compression method. Tablets were prepared using Eudragit EPO as taste masking agent, mucilage of Hibiscus rosa-sinensis used as solubility enhancer, sodium starch glycolate used as superdisintegrating agent, micro crystalline cellulose used as direct compression polymer and aspartame as sweetening agent. 32 Full factorial design was used to optimize % drug release and disintegrating time. The concentration of HRSM (X1) and concentration of SSG (X2) were selected as independent variables. The drug release (Y1) and disintegrating time (Y2) were selected as dependent variables. The prepared tablets were evaluated for thickness, hardness, weight variation, friability, wetting time and % drug content. FTIR study was carried out for drug and excipients compatibility study. Taste masking evaluation was evaluated by electronic-tongue. Raloxifene hydrochloride taste masked orodispersible tablets prepared and found to be of good quality gratifying all the requirements for orodispersible tablet. The results indicated that X1 and X2 significantly affected the % drug release (Y1) and disintegrating time (Y2). Regression analysis and numerical optimization were performed to identify the best formulation. The Taste masked orodispersible tablet of antiosteoporetic agent, raloxifene HCl was formulated successfully by direct compression method.
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