The aim of present work was to develop a topical bioadhesive gel of lornoxicam by using three level factorial design and evaluate the effects of two independent variables {amount of carbopol (934 = X1) and sodium carboxymethylcellulose (NaCMC) = X2)} on the dependent variable (bioadhesiveness, viscosity and in-vitro drug release). In the present research work, the different concentration of polymers including carbopol 934 and sodium caboxymethyl cellulose (NaCMC) were studied. The topical bioadhesive gel was evaluated for viscosity, bioadhesiveness, in-vitro studies, texture analysis and spreadability. Optimized formulation was further evaluated by in-vitro studies, in-vivo studies and accelerated stability studies. The optimized concentration of cabopol 934 and sodium caboxymethyl cellulose was found to be 1.5%. Batch A7 showed the highest bioadhesion i.e. 85g with highest in-vitro drug release i.e. 74%. It was concluded that formulated topical gel was able to show permeation and reduces the inflammation.
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