Capsaicin is the most abundant of capsaicinoid which is the pungent metabolite in the fruits of Capsicum species. Capsaicinoid is responsible for about 90% of total pungency in the fruit. Capsaicin has been used as a topical analgesic against rheumatoid arthritis pain and inflammation. The aim of the proposed research work was to formulate microemulsion incorporating chilli extract for topical therapy of rheumatoid arthritis. Eucalyptus oil/ wintergrass oil are also known to have additional benefits in the anti-inflammatory therapy. Hence the attempts were made to formulate a simple emulsion containing Capsicum frutescence extract using eucalyptus oil/ wintergrass oil. It was found that simple emulsion shows lack of solubility of the extract. Hence the approach of microemulsion was preferred to formulate microemulsion by using Span 20, Tween 60, Stearic acid was used as surfactant and Ethanol as cosurfactant. A phase diagram was constructed using Eucalyptus oil/ Wintergrass oil as oil phase. Emulgel was evaluated for influence of various temperatures, organoleptic test, pH, globule diameter, viscosity and consistency. The microemulsion formulation was found to be stable in Freeze-thaw study. The penetration of capsaicinoid from each dosage forms was evaluated using Franz diffusion cell. The result showed that chili fructus extract is containing 1.93±0.2% capsaicinoid. The percentage of penetrated capsaicinoid from emulgel dosage form was 98.118%.
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