Non-invasive transdermal drug delivery (NTDD) system in a novel method of drug delivery. This review article describes the various delivery considerations and extraneous factors in developing a strategy to pursue an alternate route of administration for systemic delivery. This system is a technique that provides drug absorption via the skin. The system has many advantages over conventional administration routes such as intravenous or oral administration for systemic and local drug delivery with simple administration. Liposomes are the vesicles that can encapsulate a drug that is unfavorable for transdermal delivery. They have been shown to be beneficial for stabilizing therapeutic compounds, overcoming obstacles to cellular and tissue uptake and improving biodistribution of compounds to target sites in-vivo. This enables effective delivery of encapsulated compounds to target sites while minimizing systemic toxicity. However, horny layer of stratum corneum (SC) is the main barrier for efficient transdermal delivery of liposomes. Iontophoresis when used with weak electric current improves the transdermal delivery of liposomes by enhancing their ability to penetrate through the skin. In this review, we provide an overview of considerations for WEC when used for transdermal drug delivery. We discuss a novel perspective on the mechanism of WEC-mediated transdermal delivery of liposomes and lastly the applications of liposomes in transdermal drug delivery system.
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