The present study aims to develop and evaluate sustained release matrix type tablets of Ofloxacin, a 4- quinolone derivative with high activity against a wide range of gram positive and gram-negative bacteria. The sustained release matrix type tablets was developed to deliver the drug in systemic circulation at constant level, so a minimum inhibitory concentration of drug is maintained in blood for an extended period of time. Xanthun gum and Guar gum were used as release retardant. Matrix-type tablets were prepared by direct compression technique. Dissolution testing was carried out using USP Apparatus I and the amount of drug released was determined by UV- Spectrophotometer at 294nm. The results showed that tablets from batches F2 and F3 were suitable for sustaining the release of drug from the matrix tablet. The release kinetics studies showed that tablets from batches F2 and F3 showed nearly zero and first order release kinetics respectively. Thus it is concluded that a sustained release formulation for Ofloxacin using Xanthun gum and Guar gum can be prepared.
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