The aim of present work was to formulate matrix type transdermal drug delivery system of Ondansetron hydrochloride using solvent evaporation technique. HPMC E 50 LV (Hydrophilic) and Eudragit RS 100 (Hydrophobic) were used as polymers in various ratios using glycerin as plasticizer to obtain controlled release of drug. Various physicochemical parameters like thickness, folding endurance, Drug Diffusion, percentage elongation, flatness, moisture content and percentage drug entrapment were studied and desirability function was applied to all the batches. The batch with maximum overall desirability value was selected as optimized batch which gave 56.92 % of drug release in 8 hours and 90.76 % of drug release after 24 hours. In vitro drug release through artificial cellulose membrane follows Higuchi kinetics and showed good correlation between relative concentration of hydrophilic and hydrophobic polymers. The compatibility of drug and polymers was studied by FT-IR and DSC. The results suggested no physicochemical incompatibility between the drug and excipients.
Loading....