The present research has been undertaken with the aim to develop a topical gel formulation for valacyclovir by using various gelling agents (viz., carbopol 934, sodium carboxy methylcellulose, guar gum and hydroxypropyl methylcellulose) in to various types of gel formulations (hydrogels, isopropyl alcoholic gels, proniosomal gels). The prepared gels were evaluated for pH, rheological behavior (viscosity, spreadability, and extrudability), drug content, in vitro drug diffusion and also characterized by IR studies. There is no interaction between drug and carrier. Drug content was found to be high (>98%) and uniform in gels. Effect of gelling agent and type of gel formulation on the release of drug from the gels was studied. The order of release of drug from various gel formulations was as follows: Hydrogel > isopropyl alcohol gel > proniosomal gel. The release of Valacyclovir was slow and extends for longer period following first order kinetics. The order of release of the drug from various gelling agents was as follows HPMC > Corbopol 934 > NaCMC > Guargum.
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