The objective of this investigation was to develop solid lipid nanoparticles (SLN) of an antihypertensive drug carvedilol with the help of hot homogenization followed by ultrasonication method. SLN were prepared by using tripalmitin as lipid at various concentrations (1, 2.5 and 5%) and tween 80 as surfactant at various concentrations (1, 1.5 and 2%). The developed SLN were characterized for particle size, polydispersity index, entrapment efficiency of carvedilol and morphology. The physicochemical interaction between carvedilol and lipid was investigated by Fourier transform infrared (FTIR) Spectroscopy. The mean particle size was found to be in the range of 50-220 nm with a narrow particle distribution of polydispersity index, 0.238. The drug entrapment efficiency (EE %) of SLNs was more than 80% and increased as the concentration of lipid was increased and decreased as the concentration of surfactant was increased. The drug release was decreased as the concentration of both lipid and surfactant was increased. In vitro release of carvedilol from SLN followed Higuchi diffusion and first order equation.
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