Objective: The aim of this research work was to design & evaluate chronomodulated pulsincap drug delivery system of Aceclofenac for arthritis. Material and Method: Aceclofenac Microcapsules prepared by solvent evaporation method using three different drug: polymer ratio (viz., 1:1, 1:2 and 1:3) were subjected to various physico- chemical studies. The optimized formulation MC2 was filled in to formaldehyde treated gelatin capsule using different concentrations (10%, 20% and 30%) of guar gum and methyl cellulose as hydrogel plugs. Further modified capsules were coated with Eudragit S-100 as enteric coating and HPMC as swellable coating by dip coat method. The prepared modified pulsincaps evaluated for physicochemical and release parameters. Key findings: In vitro release studies of all the formulations showed that there was no drug release in simulated gastric fluid (pH 1.2) for 2 hrs, negligible amount (4.48%-14.78%) of drug release was observed in simulated intestinal fluid (pH 6.8 phosphate buffer), drug release occurred in pH 7.4 upto 24 hrs in controlled manner depending upon the quantity of polymer plug. All formulations followed first order release kinetics by diffusion mechanism\r\n Conclusion: The obtained results showed the capability of the system in delaying the drug release for programmable period of time which improves the anti-inflammatory therapy in the management of rheumatoid arthritis.
Loading....