The objective of this study was to develop and evaluate a floating pulsatile drug delivery system of captopril based on an impermeable cylinder. This drug delivery system comprised of three units: impermeable cylinder, rapidly disintegrating tablets of different disintegrants in different concentration and a erodible plug. It was found that the first pulse released within 30 min. followed by a lag time of 4.5 h and finally second pulse release. Higher concentration of crosspovidone (F3 - 5 %) was responsible for maximum drug release in first and second pulse as compared to other formulation. Low viscosity polymer HPMC E5 with ratio 45:53:2 (HPMC-E5: spray dried lactose: SSG) containing erodible plug was responsible for lag time of 4.5 h. This novel technique can be effective innovation in treatment hypertension.
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