Drug delivery systems are becoming increasingly sophisticated as pharmaceutical scientists acquire a better understanding of the physicochemical and biochemical parameters pertinent to their performance. Over the past three decades, orally disintegrating tablets (ODTs) have gained considerable attention as a preferred alternative to conventional tablets and capsules due to better patient compliance. ODTs are solid dosage forms containing medicinal substances which disintegrate rapidly, usually in a matter of seconds, when placed on the tongue. An orally disintegrating tablet or orodispersible tablet (ODT) is a drug dosage form available for a limited amount of over-the-counter (OTC) and prescription medications. ODTs differ from traditional tablets in that they are designed to be dissolved on the tongue rather than swallowed whole. The ODT serves as an alternative dosage form for patients who experience dysphasia (difficulty in swallowing). The purpose of the present study was to develop and characterize fast dissolving tablets of Domperidone using direct compression and wet granulation technique. In the present study, Domperidone is the model drug. In this method the different excipients used were microcrystalline cellulose, crosscaramellose sodium, mannitol magnesium stearate. We formulate seven formulations with batch codes F1 to F7 by direct compression method. In-vitro drug release showed that almost drug was release nearer to 97 to 98 % range in 20 minutes. Depending upon cumulative drug release, in-vitro disintegration time, wetting time, there was found that direct compression method is better than wet granulation method. Depending upon cumulative drug release, in-vitro disintegration time, wetting time results, one formulation F7 was selected for further studies.
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