Plants have provided us a range of variety materials to aid improve and sustain the health of all living things either directly or indirectly. Gums and mucilages are widely used natural materials for conventional and novel dosage forms. These natural materials have advantages over synthetic ones since they are chemically inert, nontoxic, less expensive, biodegradable and widely available. The Okra (Hibiscus esculentus) mucilage is one of these vital materials. Matrix type transdermal patches containing drug Ketoprofen were prepared by solvent casting method employing a mercury substrate by using the combinations of Okra mucilage, Polyethylene glycol, Methyl and Propyl Paraben, Span-80. The transdermal patches were evaluated for their physicochemical properties like thickness, weight variation, flatness, tensile strength, hardness, folding endurance, drug content, swellability, surface pH, water vapour transmission, and in vitro permeation. IR studies indicated no interaction between drug (Ketoprofen) and Polymer (Okra mucilage). The prepared patches possessed satisfactory pre formulary and formulary characteristics. Hence, it can be concluded that Ketoprofen could be developed as a transdermal delivery system with Hibiscus Esculentus fruit mucilage that is an alternative to intravenous administration and has minimal adverse effects.
Loading....