The preparation and physico-chemical evaluation of Losartan potassium floating tablet as per 32 Factorial Design is presented. Statistical experimental design and data analysis using response surface plot and Contour plot is also illustrated. A 32 factorial design for the controlled release of Losartan potassium was used with two formulation variables - X1 (Drug: Polymer ratio) and X2 (Viscosity of polymer). Nine formulations were prepared and dissolution studies and floating characteristics were performed on these formulations. The two formulation variables were- found to be significant for the release properties (P < 0.05), while Viscosity of polymer was found to be significant for total floating time as well as % drug release. The quadratic mathematical model developed could be used to further predict formulations with desirable release and floating properties.
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