A new sustained release microencapsulated drug delivery system for acetazolamide by employing pectin was developed and characterized. The microcapsules were formulated with pectin by orifice ionic gelation technique .Polymers such as HPMC, MC, Sod.CMC, gum karaya, gum kondagogu and gum olibanum were used along with pectin. Microcapsules were evaluated for particle size, flow properties, drug entrapment efficiency, and in vitro drug release studies. . The drug release from the microcapsules was dependent on the curing reagent employed such as calcium chloride, barium chloride, aluminium chloride and zinc chloride (CaCl2, BaCl2, AlCl3 and ZnCl2). The microcapsules formulate with the curing reagent BaCl2 has shown better sustained release. The optimised formulation of microcapsules having the composition pectin: gum kondagogu: drug (0.25: 0.5:1) produced the complete release at the required release rate. The drug release of the formulation followed first order kinetics and the mechanism of drug release followed diffusion.
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