The aim of present investigation was to evaluate the potential use of mucoadhesive Carbopol 934P microspheres for gastroretentive delivery of Cefuroxime Axetil. Microspheres were prepared by spray drying technique using 32 Full factorial design. Independent variables chosen were Drug: Polymer ratio and Feed flow rate. The formulated Microspheres were characterised for Mucoadhesion time, Encapsulation Efficiency, Particle size analysis, DSC, XRD, IR and In-vitro drug release. The result of mucoadhesion study shows better retention (320±15 min) of formulation in upper part of GIT. The formulation technique shows higher encapsulation efficiency (97.21±1.09). The Particle size analysis shows better particle size (4to7 µm). The result of surface topography shows formation of matrix of drug & polymer with spherical particles. The IR spectroscopic study reveals that no structural changes during formulation. DSC thermogram shows the thermal behaviour of formulations. The release of the drug was prolonged up to 10 hrs (96.46±0.76).
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