The purpose of this review on floating drug delivery systems (FDDS) is to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. One of the most feasible approaches for achieving a prolonged and predictable dug delivery profiles in the gastrointestinal tract is to control the gastric residence time (GRT), using gastro retentive dosage forms that will provide us with new and important therapeutic options. From the formulation and technological point of view, the floating drug delivery system is considerably easy and logical approach. This dosage forms will be very much useful to deliver ‘narrow absorption window’ drugs. The developments of FDDS are including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, advantages, formulation variables and their classification are covered in detail. This review also summarizes the in vitro techniques, to evaluate the performance of floating systems.
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