The main objective of the present work was to develop sustained release matrix tablets of Indomethacin using different polymers viz. Hydroxy propyl methyl cellulose (HPMC) and natural gums like Karaya gum (KG) ,Carrageenan (CG) and tamarind gum. No interaction between drug and polymer was confirmed by FTIR, which shows the suitability of all excipients with the drug to formulate the sustained release matrix tablets. Four batches of sustained release matrix tablets of with karaya gum,carrangeenan gum , tamarind gum and HPMC K 15M were prepared by using different drug: polymer ratio i.e. 1; 2, 1:2.5, 1:3 and 1:3.5 by wet granulation method. The tablets were analyzed for their various parameters such as hardness, friability, weight variation. In- vitro release was performed with the phosphate buffer of pH 7.4 for 24 hrs. Swelling index study was carried out to study the dispersibility of gums at different concentrations. The results of in vitro drug release shows that as the concentration of gum increases, swelling index also increases proportionately. Batchs F14, F15 & F16 shows maximum drug release with sustained release rate. It is clear through the dissolution study and the kinetic release study of the Indomethacin matrix tablets prepared using tamarind gum, retarded up to 24 hrs and tamarind gum is best suitable for sustained release formulation by wet granulation method.
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