The aim of this article is to review the development of ODTs, challenges in formulation, new ODT technologies and evaluation methodologies, suitability of drug candidates, and future prospects. The purpose of formulation and development of orally disintegrating tablet (ODTs) is who have the problem of swallowing conventional tablets and capsules. ODTs have the unique property of rapidly disintegrating and/or dissolving and releasing the drug as soon as they come in contact with saliva, thus obviating the requirement of water during administration. Over the decades, orally disintegrating tablet (ODTs) has expanded much attention as a preferred alternative to conventional oral dosage form such as tablet and capsules. Recently, ODTs have acquired an important position in the market by who have difficulty in overcoming previously encountered administration problems and contributing to extension of patient life, which includes dysphagic, bed ridden, psychic, geriatric and pediatric patients, Conventional preparation technologies like direct compression, lyophilization, spray drying, molding, phase transition process, melt granulation, sublimation, mass extrusion, etc., while various patented technologies like Zydis, Orasolv, Durasolv, Flash tab, Oraquick, Wow tab, etc., have been developed for the production of ODTs, with evaluate the potential of microspheres for taste masking when incorporated into orally disintegrating tablets including the use of superdisintegants. The present review addresses briefly about the current developments in ODT technologies and various leading technologies for their manufacturing. In addition, important aspects of ODT technology are discussed.
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