In recent decades, a variety of pharmaceutical research has been conducted to develop new dosage forms. Among the dosage forms developed to facilitate ease of medication, the mouth dissolving tablet (MDT) is one of the most widely employed commercial products. Mouth dissolving tablets have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. Upon introduction into the mouth, these tablets dissolve or disintegrate in the mouth in the absence of additional water for easy administration of active pharmaceutical ingredients. The development of Fast or mouth dissolving tablets have been formulated for pediatric, geriatric, and bedridden patients and for active patients who are busy and traveling and may not have access to water. Such formulations provide an opportunity for product line extension in the many elderly persons will have difficulties in taking conventional oral dosage forms (viz., solutions, suspensions, tablets, and capsules) because of hand tremors and dysphagia. This article summarizes contents of formulation, various approaches of preparation of MDT like melt granulation, phase transition process, sublimation, three-dimensional printing (3DP), mass extrusion, spray drying, cotton candy process, tablet molding, lyophilization or freeze-drying, direct compression, nanomization, etc., various patented technologies like zydis, orasolv, durasolv, wowtab, flashtab, shearform, ceform, nanocrystal and evaluation parameter in detail.
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