Systemic bioavailability of many drugs are not being effectively and efficiently achieved using conventional drug delivery approaches due to its complexity. Nasal drug delivery is an alternative approach to the systemic and enteral drug delivery. It avoids presystemic firstpass metabolism and gastric acid hydrolysis of drugs results in increasing the bioavailability. Nasal route gives reduced dosing frequency for bioadhesive controlled release formulations. The nasal mucosa offers direct access to the compartment of the central nervous system via the olfactory route. This review explains the details on anatomy and physiology of nose, mechanism, factors affecting for drug absorption, various approaches, Applications for the nasal dug delivery.
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