The ultimate goal of any drug delivery system is the successful delivery of the drug to the body; however patient compliance must not be exculpated. Fast dissolving drug delivery systems such as, Oral Thin Strip (OTS), offer a convenient way of dosing medications, to special population groups with swallowing difficulties such as children and the elderly, and also to the general population. OTS is the novel dosage form that disintegrates and dissolves within the oral cavity. Intra-oral absorption permits rapid onset of action and helps by-pass first-pass effects, therefore reducing the unit dose required to produce desired therapeutic effect. The present review provides an overview of various polymers that can be employed in the manufacture of OTS and highlights the effect of polymers and plasticizers on various physico-mechanical properties of OTS. It further gives a brief account of formulation of OTF and its objective is to compile the recent advancements and literature regarding the fast dissolving films and its market prospects.
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