Hot-melt granulation is an established process that has been used since the early 1930s, predominately in the plastics manufacturing industry, but also in the food processing industry. Currently, it is an emerging field in Novel drug delivery system. Hot Melt Granulation is becoming an important technology within the Pharmaceutical Industry as a means for formulating poorly water-soluble active pharmaceutical ingredients (API’s) and sustained release formulation. In this article containing marketed sustained release tablet compare with this formulation. First of all done authentication test for drug sample and got same result as per data, Differential scanning colorimetry and infra red spectroscopy for compatibility and ensure that whatever wax and polymer used in this formulation is compactable with drug, flow properties for flow of granules, compressibility. List of suitable three wax containing carnauba wax give good result, same way different grade of Hypromallose among them HPMCK100M give good result for sustained release formulation. Carnauba wax, Hypromallose and drug were observed better dissolution release profile for sustained release tablet formulation. There were got good result for this formulation. And last done the stability study of this product.
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