Recently self emulsifying drug delivery system has gained popularity among all other formulation strategies used for poorly water soluble drugs. The objective of the present study was to develop and characterize self-micro emulsifying drug delivery system (SMEDDS) of the poorly water-soluble drug, Glibenclamide (GBD). Solubility of GBD was determined in various oily vehicles. From the solubility study, better solubility was seen in Captex 200P (oil), Cremophor RH40 (surfactant), Capmul MCM C8 (co-surfactant). Phase diagrams were constructed to identify efficient self-emulsification region using oils, surfactants, and cosurfactants in aqueous environment. Formulations were prepared according to 32 full factorial design using two variables oil : Smix (X1) and S : Cos (X2) and their effects were evaluated for three responses like droplet size, self emulsification time and % drug release at 15 min. All the nine batches were assessed for dispersibility, emulsification time, % transmission, viscosity, zeta potential, particle size, electro conductivity, drug content, and dissolution studies. In vitro drug dissolution was carried out using USP type-II apparatus and compared with that of marketed GBD tablet (Daonil®) and dissolution was found to be increased in case of SMEDDS than marketed tablet formulation. Effects of various formulation variables on different responses were extracted out by using Design Expert® software. From that study it was found that X1 variable negatively affect self emulsification time while droplet size was negatively affected by X2 variable. From all desired responses batch G6 was considered as optimized batch. Optimized batch was found to be stable at ambient conditions for one month of storage.
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