In order to enhance the delivery of poorly-soluble drugs, aquasomes will be the promising nanocarrier as the novel drug delivery system. These are nanoparticulate carrier systems with three layered self-assembling composition with ceramic carbon nanocrystalline particle core coated with polyhydroxy oligomers. Subsequently drug covalently bonded to outer coating. Three types of core materials are mainly used for producing aquasomes: tin oxide, nanocrystalline carbon ceramics (diamonds) and brushite (calcium phosphate dihydrate). Calcium phosphate is the core of interest, owing to its natural presence in the body. Aquasome deliver their content through specific targeting, molecular shielding and slow sustained release process. The polyhydroxy oligomer layer ensures that they have the dual advantage of protecting the native conformation of drugs and imparting water-like properties for enhanced dissolution. The nano-size dimensions ensure superior surface area for the enhanced dissolution of hydrophobic molecules.
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