The purpose of writing this review on Stomach specific dosage forms for technological attempts have been made in the research and development of rate-controlled oral drug delivery systems to overcome physiological adversities, including the physiological and formulation variables affecting gastric retention and unpredictable gastric emptying times (GET). It is known that differences in gastric physiology, such as, gastric pH, and motility exhibit both intra-as well as inter-subject variability demonstrating significant impact on gastric retention time and drug delivery behaviour. We have reviewed various gastroretentive approaches designed and developed until now, i.e. high density, floating, bio-or mucoadhesive, expandable, unfoldable, super porous hydrogel and magnetic systems, classification and formulation aspects are covered in detail.
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