From the last two decades the main focus of formulation scientists is the modification of release pattern of active moiety from the dosage form and tailoring the same by modification of drug delivery system, also by changing the site of drug release. Taking the advantage of physiological studies and parameters affecting the drug release at the same time studies on newer excipients gave birth to the site specific and release modified novel drug delivery systems. In the present review the formulation and physiological aspects for developing the efficient Gastrortentive Floating Drug Delivery Systems (GRFDDS) are considered. Gastric retention time can be increased by different ways but when the drug has absorption window in the upper region of GI and/or shows erratic bioavailability. Such drugs can be well formulated by using low density inactives thus making it to float on the gastric content and get retained in stomach providing drug release near absorption window over a long time. In the present article various aspects like basic gastrointestinal tract physiology, rational for developing and types of GRFDDS, physiological and formulation factors affecting buoyancy and drug release to be considered while developing floating drug delivery systems, recent advances, potential applications for GRFDDS are considered.
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