Novel drug delivery systems (NDDS) constitute the mainstay of pharmaceutical research and development. A significant milestone in oral NDDS is the development of the osmotic drug delivery system, an innovative and highly versatile drug delivery system. Osmotic drug delivery systems utilize the principle of osmotic pressure, as an energy source, for the delivery of drugs. Oral osmotic drug delivery systems with their versatility and their highly predictable drug release rates offer various biomedical advantages. Osmosis is an aristocratic phenomenon that seizes the attention for its exploitation in zero-order drug delivery systems. The drug delivered from these systems is independent of pH and the physiological conditions. Optimizing semi permeable membrane and the osmotic agents can modulate drug release from the system. In this article, a detailed description of various oral osmotically driven systems along with their formulation aspects, therapeutic applications and evaluation techniques are described.
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